Pretty darn good -- these come closer to relieving my sole issues than any other socks I've tried. I think the compression factor helped to reduce the swelling I get after 4 or 5 miles (which produces inlammation), and the wicking and the yarn and the seamless structure all helped to reduce friction. Still a couple of hot spots after 9 miles. If OS1st would like to use my feet as subjects for research and development, I'll happily volunteer.